Researchers from CeMM and the University of Oxford have uncovered crucial insights into NUDT5’s involvement in leukemia. Their findings indicate that eliminating NUDT5 leads to heightened resistance of cancer cells to 6-thioguanine, surpassing the effects of merely blocking its function. Notably, they also discovered a link between NUDT5 and the protein NUDT15, revealing varied pathways of drug response.
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